CosMx Spatial Molecular Imager
High fidelity, high sensitivity, subcellular imaging of the whole transcriptome with proteomics for complete pathway-level spatial insights
Whole transcriptome subcellular imaging with same-cell multiomics
Further, CosMx® Spatial Molecular Imager (SMI) is the only single-cell whole transcriptome spatial platform to provide same-cell spatial multiomics in formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) tissue samples at single cell and subcellular resolution.
Exploring Spatial Transcriptomics
Discover how spatial transcriptomics reveals what genes are expressed, which cells express them, and where they are located.
Introduction to the CosMx SMI Platform
Explore the power of CosMx SMI and see how high-plex single-cell spatial biology can unlock deeper biological insights otherwise missed.
Uncover discoveries otherwise missed
Unmatched detection efficiency to deliver the highest number of transcripts and unique genes per cell.
After the CosMx 2.0 update, CosMx instruments demonstrate up to a 2x increase in RNA detection efficiency across all commercial RNA assays. This includes both 1K and 6K targeted panels and enables more transcripts to be detected per cell.
The CosMx 2.0 update also supports the CosMx Whole Transcriptome (WTX) assay, making CosMx the first and only spatial platform to image the entire protein-encoding transcriptome inside every single cell. Our new WTX technology lets you reveal complete biology with subcellular whole transcriptome imaging for uncharted discoveries. The WTX assay is now shipping
Subcellular Whole Transcriptome Imaging
From inferring to projecting complete biological pathways directly onto the tissue
First spatial platform to image the entire protein-encoding transcriptome inside every single cell
CosMx® Whole Transcriptome (WTX) assays are designed to measure the full protein-coding transcriptome with single-cell and subcellular spatial resolution in intact FFPE and fresh frozen tissue. By combining transcriptome-scale coverage with high fidelity and high-sensitivity spatial imaging, WTX enables complete pathway-level spatial insights.
Subcellular Analysis
Preserve the vital link between tissue morphology, RNA, and protein with subcellular resolution
Mapping the intracellular landscape with RNA and protein together at subcellular resolution
The ability to simultaneously map morphology, RNA, and protein at the subcellular level is the new frontier in cell biology. While the CosMx® Spatial Molecular Imager (SMI) is renowned for tissue analysis, it is also a powerhouse for in vitro applications, detecting diverse biomolecules in situ at nanometer precision. Unlike traditional dissociation methods like bulk or single cell RNA-seq that strip cells of their context, CosMx SMI enables direct subcellular spatial measurements that preserve the vital link between native morphology and microenvironmental context.
Find the Right Platform for Your Research
| Platform | CosMx | CellScape | GeoMx | nCounter | PaintScape |
|---|---|---|---|---|---|
| Applications | High fidelity, high sensitivity, subcellular imaging of the whole transcriptome with proteomics for complete pathway-level spatial insights | High fidelity, flexible subcellular proteomics for rapid and quantitative spatial phenotyping | High fidelity, unmatched discovery multiomics to profile from cells to tissue structures for spatial breakthroughs at scale | Rapid and robust targeted RNA and multiomic expression proven for translational and clinical studies | High fidelity, high precision multiplexed direct visualization of spatial organization of the 3D genome |
| Analyte | RNA, protein | Protein, RNA | RNA, protein | miRNA, Protein, RNA | DNA |
| Plex level | Target RNA assays (up to 6000 targets) Whole transcriptome RNA assays Up to 64 proteins |
Targeted protein assays (up to 34 targets) Customizable assays up to 20 |
Targeted RNA assays (up to 2000 targets) Whole transcriptome RNA assays Up to 1200 proteins |
800+ RNA 500+ protein |
Targeted DNA Assays (419+ targets) |
| Resolution | Single-cell Subcellular |
Single-cell Subcellular |
Multicellular (RNA) Single-cell (protein) |
Bulk | Single-nuclei |
| Sample compatibility | FFPE, FF, organoids, cultured cells | FFPE, FF, cell suspension, lysate | FFPE, FF | FFPE, FF, lysate | Human cell lines, FF tissue (coming soon) |
| Data readout | Imaging | Imaging | NGS, nCounter (Direct counting) | nCounter (Direct counting) | Imaging |
