
Bruker Spatial Biology, a division of Bruker Corporation, delivers best‑in‑class solutions for capturing the full complexity of biology. Through a cohesive portfolio of high fidelity instruments, assays, software, and services — each fit-for-purpose for its respective omic and designed to work together as a multiomic ecosystem — Bruker Spatial Biology enables researchers to visualize and quantify biology across DNA, RNA, and protein, generating insights that are difficult to achieve by studying any single omic alone.
The CosMx® Spatial Molecular Imager is built for high sensitivity subcellular imaging of the whole transcriptome for complete pathway-level spatial insights, supported by the AtoMx® Spatial Informatics Platform for AI‑driven 3D cell segmentation and study‑level data exploration. The GeoMx® Digital Spatial Profiler is optimized for unmatched discovery spatial multiomics, combining whole transcriptome analysis with more than 1,200 proteins to profile from cells to tissue structures for spatial breakthroughs at scale. The CellScape™ XR platform is built for flexible, subcellular proteomics for rapid and quantitative spatial phenotyping, while the PaintScape™ platform is optimized for high precision, multiplexed direct visualization of the 3D genome. The nCounter® Analysis System provides highly robust bulk multiomic analysis for rapid biomarker discovery and development.
Together, these solutions are supported by a global team of scientists, sales, and service professionals, along with Bruker Spatial Biology CRO Services for biopharmaceutical research, assay development, and clinical sample testing.
Find the Right Platform for Your Research
| Platform | CosMx | CellScape | GeoMx | nCounter | PaintScape |
|---|---|---|---|---|---|
| Applications | High fidelity, high sensitivity, subcellular imaging of the whole transcriptome with proteomics for complete pathway-level spatial insights | High fidelity, flexible subcellular proteomics for rapid and quantitative spatial phenotyping | High fidelity, unmatched discovery multiomics to profile from cells to tissue structures for spatial breakthroughs at scale | Rapid and robust targeted RNA and multiomic expression proven for translational and clinical studies | High fidelity, high precision multiplexed direct visualization of spatial organization of the 3D genome |
| Analyte | RNA, protein | Protein, RNA | RNA, protein | miRNA, Protein, RNA | DNA |
| Plex level | Target RNA assays (up to 6000 targets) Whole transcriptome RNA assays Up to 64 proteins | Targeted protein assays (up to 34 targets) Customizable assays up to 20 | Targeted RNA assays (up to 2000 targets) Whole transcriptome RNA assays Up to 1200 proteins | 800+ RNA 500+ protein | Targeted DNA Assays (419+ targets) |
| Resolution | Single-cell Subcellular | Single-cell Subcellular | Multicellular (RNA) Single-cell (protein) | Bulk | Single-nuclei |
| Sample compatibility | FFPE, FF, organoids, cultured cells | FFPE, FF, cell suspension, lysate | FFPE, FF | FFPE, FF, lysate | Human cell lines, FF tissue (coming soon) |
| Data readout | Imaging | Imaging | NGS, nCounter (Direct counting) | nCounter (Direct counting) | Imaging |













